Updated for May 2026
Every 2026 GLP-1, side by side.
Independent reviews of every oral and injection GLP-1 receptor agonist available in 2026, with verified pricing, Medicare GLP-1 Bridge coverage, and food-restriction status.
Oral GLP-1s (5)
Foundayo (orforglipron)
No food restrictions Editor's PickOral GLP-1 · Once daily
Avg loss
12–16%
Self-pay from
$149/mo
Plans
42
No food OR water
Rybelsus (semaglutide (oral))
Oral GLP-1 · Once daily
Avg loss
8–10%
Self-pay from
$998/mo
Plans
78
30-min fast required
Wegovy Tablets (semaglutide HD-oral)
Editor's PickOral GLP-1 · Once daily
Avg loss
12–15%
Self-pay from
$149/mo
Plans
31
Empty stomach
Qsymia (phentermine + topiramate ER)
No food restrictionsOral GLP-1 · Once daily
Avg loss
7–11%
Self-pay from
$230/mo
Plans
28
Take in the morning (avoid evening)
Contrave (naltrexone HCl + bupropion HCl ER)
Oral GLP-1 · Once daily
Avg loss
5–9%
Self-pay from
$650/mo
Plans
35
Avoid high-fat meals
Injection GLP-1s (4)
Included for context — when an oral pill won't deliver enough weight loss for your goal.
Mounjaro (tirzepatide (T2D injection))
No food restrictionsOral GLP-1 · weekly
Avg loss
12–16%
Self-pay from
$1069/mo
Plans
92
No food restriction
Zepbound (tirzepatide (injection))
No food restrictionsOral GLP-1 · weekly
Avg loss
18–22%
Self-pay from
$299/mo
Plans
60
No food restriction
Ozempic (semaglutide (T2D injection))
No food restrictionsOral GLP-1 · weekly
Avg loss
5–8%
Self-pay from
$998/mo
Plans
95
No food restriction
Saxenda (liraglutide (daily injection))
No food restrictionsOral GLP-1 · Once daily
Avg loss
5–8%
Self-pay from
$1349/mo
Plans
22
No food restriction