Updated for May 2026

The 2026 oral GLP-1 you'll actually qualify for.

Independent reviews of Foundayo, Rybelsus, and Wegovy Tablets — with verified partner pricing, Medicare coverage (post Jul 1), and a 30-second eligibility match.

Match me with a 2026 pill

9
weight-loss meds ranked daily: $149/mo
lowest verified 2026 price: $50/mo
Medicare Bridge from Jul 1, 2026

Every claim cites a primary source

FDA labels · 8 NEJM · 5 Lancet · 1 CMS · 1 All sources →

Prescription Matcher

3-step qualifier · ~30 seconds · Not a prescription

1

Goal
2

Preference
3

Result

Step 1 · Your Goal

How much weight would you like to lose?

35lbs

Estimated category

Moderate (10–18%)

10 lb50 lb100+ lb

2026 Oral GLP-1 Comparison

Verified May 2026 Medicare Bridge Jul 1

Side-by-side data on every oral GLP-1 available or pending in 2026.

Oral GLP-1 medications compared on efficacy, food restriction, monthly price, and Medicare coverage.
Medication	Avg weight loss	A1c	Food restriction	Self-pay /mo* Insurance co-pay /mo*	Coverage	Action
Foundayo Editor's Pick orforglipron · tablet · daily · 2026 launch	12–16%	—	No food OR water	$149 $50 partner pharmacy with prior auth	Medicare: $50/mo (Jul 1 ✓) 42 plans	See pricing
Wegovy Tablets Editor's Pick semaglutide HD-oral · tablet · daily · Now Available · Jan 2026	12–15%	—	Empty stomach	$149 $50 partner pharmacy with prior auth	Medicare: $50/mo (Jul 1 ✓) 31 plans	See pricing
Rybelsus semaglutide (oral) · tablet · daily · Established · T2D oral	8–10%	−1.4%	30-min fast required	$998 — partner pharmacy with prior auth	Medicare: Tier 4 78 plans	See pricing
Mounjaro tirzepatide (T2D injection) · injection · weekly · Established · T2D	12–16%	−2.4%	No food restriction	$1069 — partner pharmacy with prior auth	Medicare: Tier 4 92 plans	See pricing
Zepbound tirzepatide (injection) · injection · weekly · Strongest in class · Injection	18–22%	—	No food restriction	$299 $50 partner pharmacy with prior auth	Medicare: $50/mo (Jul 1 ✓) 60 plans	See pricing
Ozempic semaglutide (T2D injection) · injection · weekly · Established · Weekly injection	5–8%	−1.8%	No food restriction	$998 — partner pharmacy with prior auth	Medicare: Tier 4 95 plans	See pricing
Qsymia phentermine + topiramate ER · tablet · daily · REMS-restricted · Non-GLP-1	7–11%	—	Take in the morning (avoid evening)	$230 — partner pharmacy with prior auth	Medicare: Tier 3 28 plans	See pricing
Saxenda liraglutide (daily injection) · injection · daily · Daily injection · Older option	5–8%	—	No food restriction	$1349 — partner pharmacy with prior auth	Medicare: Tier 4 22 plans	See pricing
Contrave naltrexone HCl + bupropion HCl ER · tablet · daily · Non-GLP-1 alternative	5–9%	—	Avoid high-fat meals	$650 — partner pharmacy with prior auth	Medicare: Tier 3 35 plans	See pricing

Foundayo (orforglipron)

No food restrictions Editor's Pick

Oral GLP-1 · Once daily

Avg loss

12–16%

Self-pay from

$149/mo

Plans

No food OR water

Read full Foundayo guide → See pricing

Wegovy Tablets (semaglutide HD-oral)

Rybelsus (semaglutide (oral))

Oral GLP-1 · Once daily

Avg loss

8–10%

Self-pay from

$998/mo

Plans

30-min fast required

Read full Rybelsus guide → See pricing

Mounjaro (tirzepatide (T2D injection))

No food restrictions

Oral GLP-1 · weekly

Avg loss

12–16%

Self-pay from

$1069/mo

Plans

No food restriction

Read full Mounjaro guide → See pricing

Zepbound (tirzepatide (injection))

No food restrictions

Oral GLP-1 · weekly

Avg loss

18–22%

Self-pay from

$299/mo

Plans

No food restriction

Read full Zepbound guide → See pricing

Ozempic (semaglutide (T2D injection))

No food restrictions

Oral GLP-1 · weekly

Avg loss

5–8%

Self-pay from

$998/mo

Plans

No food restriction

Read full Ozempic guide → See pricing

Qsymia (phentermine + topiramate ER)

No food restrictions

Oral GLP-1 · Once daily

Avg loss

7–11%

Self-pay from

$230/mo

Plans

Take in the morning (avoid evening)

Read full Qsymia guide → See pricing

Saxenda (liraglutide (daily injection))

No food restrictions

Oral GLP-1 · Once daily

Avg loss

5–8%

Self-pay from

$1349/mo

Plans

No food restriction

Read full Saxenda guide → See pricing

Contrave (naltrexone HCl + bupropion HCl ER)

Oral GLP-1 · Once daily

Avg loss

5–9%

Self-pay from

$650/mo

Plans

Avoid high-fat meals

Read full Contrave guide → See pricing

Verified 2026 Telehealth Partners

Independently scored on price transparency, prescriber credentials, and refill reliability. We earn commissions from some partners — see editorial standards.

Live inventory Updated daily

LillyDirect

Direct from Eli Lilly

Lowest 2026 cash price

4.7 (8,420)

In Stock · Shipping 24h

Verified 2026 price

$149/mo

self-pay · Foundayo from $149/mo

Visit & shipping

Free intake

2-day shipping

Direct from manufacturer pricing
No insurance required
Auto-refill with on-time discount

HIPAA Compliant Verified 2026

Check Eligibility

PlushCare

Telehealth GLP-1 with broad insurance acceptance

Best for insurance

4.7 (8,200)

Telehealth visits available next-day

Verified 2026 price

$199/mo

$129 first visit cash · $30 copay with insurance · $19.99/mo membership

Visit & shipping

$129 visit

Mail-order via partner pharmacy

In-network with Aetna, Cigna, UnitedHealthcare, Anthem, Humana + 100 plans
Prescribes branded GLP-1s only (no compounded)
Ongoing dose adjustments included in $19.99/mo membership

HIPAA Compliant Verified 2026

Check Eligibility

NovoCare

Direct from Novo Nordisk

Best for Wegovy Tablets

4.6 (6,240)

In Stock · Same-day Rx

Verified 2026 price

$149/mo

self-pay · Wegovy pill from $149/mo

Visit & shipping

Free intake

Mail-order pharmacy

Manufacturer-direct pricing for Novo products
Savings card stacking on insurance
Pharmacist Q&A line

HIPAA Compliant Verified 2026

Check Eligibility

Sesame

Pay-per-visit telehealth marketplace

Lowest cash visit fee

4.6 (14,500)

Same-day video visits available

Verified 2026 price

$149/mo

$39 first visit · $59/mo Success program (annual) · Wegovy pill from $149/mo

Visit & shipping

$39 visit

Pharmacy pickup or mail-order

No subscription required — pay per visit
Costco partnership: 50% off branded Wegovy for members
Branded Wegovy pills from $149/mo (lower doses)

HIPAA Compliant Verified 2026

Check Eligibility

Ro

Telehealth + retail pharmacy

Most flexible coverage

4.5 (18,420)

In Stock · Shipping 48h

Verified 2026 price

$145/mo

$45 first month, then $145/mo membership

Visit & shipping

$45 visit

Mail-order or pickup

Accepts major insurance
Wegovy pill + Foundayo carried
A1c monitoring included

HIPAA Compliant Verified 2026

Check Eligibility

Hims & Hers

Direct partnership with Novo

Direct Wegovy pill access

4.4 (22,840)

Limited · 4-day backorder

Verified 2026 price

$149/mo

$39 first month, then $149/mo

Visit & shipping

$39 visit

Discreet mail-order

Novo Nordisk-supplied Wegovy pill
Mobile-first care
Subscription pause anytime

HIPAA Compliant Verified 2026

Check Eligibility

The 2026 oral GLP-1 you'll actually qualify for.

Prescription Matcher

How much weight would you like to lose?

Any deal-breakers?

Your top oral GLP-1 match

Other strong matches

No medications match your preferences.

2026 Oral GLP-1 Comparison

Foundayo (orforglipron)

Wegovy Tablets (semaglutide HD-oral)

Rybelsus (semaglutide (oral))

Mounjaro (tirzepatide (T2D injection))

Zepbound (tirzepatide (injection))

Ozempic (semaglutide (T2D injection))

Qsymia (phentermine + topiramate ER)

Saxenda (liraglutide (daily injection))

Contrave (naltrexone HCl + bupropion HCl ER)

Verified 2026 Telehealth Partners

LillyDirect

PlushCare

NovoCare

Sesame

Ro

Hims & Hers

Your pricing sheet is ready.

The 2026 oral GLP-1 you'll actually qualify for.

How much weight would you like to lose?

Any deal-breakers?

Your top oral GLP-1 match

Other strong matches

No medications match your preferences.

2026 oral GLP-1 comparison matrix

Foundayo (orforglipron)

Wegovy Tablets (semaglutide HD-oral)

Rybelsus (semaglutide (oral))

Mounjaro (tirzepatide (T2D injection))

Zepbound (tirzepatide (injection))

Ozempic (semaglutide (T2D injection))

Qsymia (phentermine + topiramate ER)

Saxenda (liraglutide (daily injection))

Contrave (naltrexone HCl + bupropion HCl ER)

Verified 2026 Telehealth Partners

LillyDirect

PlushCare

NovoCare

Sesame

Ro

Hims & Hers