Updated May 2026
Wegovy Tablets vs Zepbound
Side-by-side comparison of Wegovy Tablets (semaglutide HD-oral) and Zepbound (tirzepatide (injection)) across efficacy, food restrictions, monthly cost, and Medicare Bridge coverage.
Our pick for most patients
Wegovy Tablets
Based on the data below, Wegovy Tablets wins on lower cash price ($149/mo vs $299/mo). Your situation may differ — try the personalized matcher on the homepage or compute your real out-of-pocket with the cost calculator on each medication's detail page.
| Field | Wegovy Tablets | Zepbound |
|---|---|---|
| Route | tablet · daily | injection · weekly |
| Avg weight loss | 12–15% | 18–22% |
| Food restriction | Empty stomach | No food restriction |
| Cash from | $149/mo | $299/mo |
| Savings card | — | — |
| Medicare Bridge | $50/mo ✓ | $50/mo ✓ |
| A1c reduction | — | — |
| FDA approved | 2025-12 | 2023-11 |
- RouteWegovy Tabletstablet · dailyZepboundinjection · weekly
- Avg weight lossWegovy Tablets12–15%Zepbound18–22%
- Food restrictionWegovy TabletsEmpty stomachZepboundNo food restriction
- Cash fromWegovy Tablets$149/moZepbound$299/mo
- Savings cardWegovy Tablets—Zepbound—
- Medicare BridgeWegovy Tablets$50/mo ✓Zepbound$50/mo ✓
- A1c reductionWegovy Tablets—Zepbound—
- FDA approvedWegovy Tablets2025-12Zepbound2023-11
Pick Wegovy Tablets if…
- You're on Medicare and want the $50/mo Bridge price
- Cash pay matters more than peak weight loss ($149/mo cheaper)
- You're needle-averse
Pick Zepbound if…
- You can't reliably do a fasting window before meds
- You're on Medicare and want the $50/mo Bridge price
- You want the higher peak efficacy (22% vs 15%)
Not sure which fits?
The 30-second matcher on the homepage scores every 2026 GLP-1 against your goals + preferences and recommends the best fit.