Updated May 2026
Qsymia vs Wegovy Tablets
Side-by-side comparison of Qsymia (phentermine + topiramate ER) and Wegovy Tablets (semaglutide HD-oral) across efficacy, food restrictions, monthly cost, and Medicare Bridge coverage.
Our pick for most patients
Wegovy Tablets
Based on the data below, Wegovy Tablets wins on covered under the Medicare GLP-1 Bridge ($50/mo from Jul 1, 2026). Your situation may differ — try the personalized matcher on the homepage or compute your real out-of-pocket with the cost calculator on each medication's detail page.
Qsymia
phentermine + topiramate ER · Vivus LLC
Take in the morning (avoid evening)
Full Qsymia guide → | Field | Qsymia | Wegovy Tablets |
|---|---|---|
| Route | tablet · daily | tablet · daily |
| Avg weight loss | 7–11% | 12–15% |
| Food restriction | Take in the morning (avoid evening) | Empty stomach |
| Cash from | $230/mo | $149/mo |
| Savings card | — | — |
| Medicare Bridge | Tier 3 | $50/mo ✓ |
| A1c reduction | — | — |
| FDA approved | 2012-07 | 2025-12 |
- RouteQsymiatablet · dailyWegovy Tabletstablet · daily
- Avg weight lossQsymia7–11%Wegovy Tablets12–15%
- Food restrictionQsymiaTake in the morning (avoid evening)Wegovy TabletsEmpty stomach
- Cash fromQsymia$230/moWegovy Tablets$149/mo
- Savings cardQsymia—Wegovy Tablets—
- Medicare BridgeQsymiaTier 3Wegovy Tablets$50/mo ✓
- A1c reductionQsymia—Wegovy Tablets—
- FDA approvedQsymia2012-07Wegovy Tablets2025-12
Pick Qsymia if…
- You can't reliably do a fasting window before meds
Pick Wegovy Tablets if…
- You're on Medicare and want the $50/mo Bridge price
- Cash pay matters more than peak weight loss ($149/mo cheaper)
- You want the higher peak efficacy (15% vs 11%)
Not sure which fits?
The 30-second matcher on the homepage scores every 2026 GLP-1 against your goals + preferences and recommends the best fit.