Updated May 2026
Ozempic vs Wegovy Tablets
Side-by-side comparison of Ozempic (semaglutide (T2D injection)) and Wegovy Tablets (semaglutide HD-oral) across efficacy, food restrictions, monthly cost, and Medicare Bridge coverage.
Our pick for most patients
Wegovy Tablets
Based on the data below, Wegovy Tablets wins on covered under the Medicare GLP-1 Bridge ($50/mo from Jul 1, 2026). Your situation may differ — try the personalized matcher on the homepage or compute your real out-of-pocket with the cost calculator on each medication's detail page.
| Field | Ozempic | Wegovy Tablets |
|---|---|---|
| Route | injection · weekly | tablet · daily |
| Avg weight loss | 5–8% | 12–15% |
| Food restriction | No food restriction | Empty stomach |
| Cash from | $998/mo | $149/mo |
| Savings card | — | — |
| Medicare Bridge | Tier 4 | $50/mo ✓ |
| A1c reduction | −1.8% | — |
| FDA approved | 2017-12 | 2025-12 |
- RouteOzempicinjection · weeklyWegovy Tabletstablet · daily
- Avg weight lossOzempic5–8%Wegovy Tablets12–15%
- Food restrictionOzempicNo food restrictionWegovy TabletsEmpty stomach
- Cash fromOzempic$998/moWegovy Tablets$149/mo
- Savings cardOzempic—Wegovy Tablets—
- Medicare BridgeOzempicTier 4Wegovy Tablets$50/mo ✓
- A1c reductionOzempic−1.8%Wegovy Tablets—
- FDA approvedOzempic2017-12Wegovy Tablets2025-12
Pick Ozempic if…
- You can't reliably do a fasting window before meds
Pick Wegovy Tablets if…
- You're on Medicare and want the $50/mo Bridge price
- Cash pay matters more than peak weight loss ($149/mo cheaper)
- You're needle-averse
- You want the higher peak efficacy (15% vs 8%)
Not sure which fits?
The 30-second matcher on the homepage scores every 2026 GLP-1 against your goals + preferences and recommends the best fit.