Updated May 2026
Mounjaro vs Wegovy Tablets
Side-by-side comparison of Mounjaro (tirzepatide (T2D injection)) and Wegovy Tablets (semaglutide HD-oral) across efficacy, food restrictions, monthly cost, and Medicare Bridge coverage.
Our pick for most patients
Wegovy Tablets
Based on the data below, Wegovy Tablets wins on covered under the Medicare GLP-1 Bridge ($50/mo from Jul 1, 2026). Your situation may differ — try the personalized matcher on the homepage or compute your real out-of-pocket with the cost calculator on each medication's detail page.
Mounjaro
tirzepatide (T2D injection) · Eli Lilly and Company
No food restriction
Full Mounjaro guide → | Field | Mounjaro | Wegovy Tablets |
|---|---|---|
| Route | injection · weekly | tablet · daily |
| Avg weight loss | 12–16% | 12–15% |
| Food restriction | No food restriction | Empty stomach |
| Cash from | $1069/mo | $149/mo |
| Savings card | — | — |
| Medicare Bridge | Tier 4 | $50/mo ✓ |
| A1c reduction | −2.4% | — |
| FDA approved | 2022-05 | 2025-12 |
- RouteMounjaroinjection · weeklyWegovy Tabletstablet · daily
- Avg weight lossMounjaro12–16%Wegovy Tablets12–15%
- Food restrictionMounjaroNo food restrictionWegovy TabletsEmpty stomach
- Cash fromMounjaro$1069/moWegovy Tablets$149/mo
- Savings cardMounjaro—Wegovy Tablets—
- Medicare BridgeMounjaroTier 4Wegovy Tablets$50/mo ✓
- A1c reductionMounjaro−2.4%Wegovy Tablets—
- FDA approvedMounjaro2022-05Wegovy Tablets2025-12
Pick Mounjaro if…
- You can't reliably do a fasting window before meds
- You want the higher peak efficacy (16% vs 15%)
Pick Wegovy Tablets if…
- You're on Medicare and want the $50/mo Bridge price
- Cash pay matters more than peak weight loss ($149/mo cheaper)
- You're needle-averse
Not sure which fits?
The 30-second matcher on the homepage scores every 2026 GLP-1 against your goals + preferences and recommends the best fit.