Updated May 2026
Contrave vs Wegovy Tablets
Side-by-side comparison of Contrave (naltrexone HCl + bupropion HCl ER) and Wegovy Tablets (semaglutide HD-oral) across efficacy, food restrictions, monthly cost, and Medicare Bridge coverage.
Our pick for most patients
Wegovy Tablets
Based on the data below, Wegovy Tablets wins on covered under the Medicare GLP-1 Bridge ($50/mo from Jul 1, 2026). Your situation may differ — try the personalized matcher on the homepage or compute your real out-of-pocket with the cost calculator on each medication's detail page.
Contrave
naltrexone HCl + bupropion HCl ER · Nalpropion Pharmaceuticals (Currax Pharmaceuticals)
Avoid high-fat meals
Full Contrave guide → | Field | Contrave | Wegovy Tablets |
|---|---|---|
| Route | tablet · daily | tablet · daily |
| Avg weight loss | 5–9% | 12–15% |
| Food restriction | Avoid high-fat meals | Empty stomach |
| Cash from | $650/mo | $149/mo |
| Savings card | — | — |
| Medicare Bridge | Tier 3 | $50/mo ✓ |
| A1c reduction | — | — |
| FDA approved | 2014-09 | 2025-12 |
- RouteContravetablet · dailyWegovy Tabletstablet · daily
- Avg weight lossContrave5–9%Wegovy Tablets12–15%
- Food restrictionContraveAvoid high-fat mealsWegovy TabletsEmpty stomach
- Cash fromContrave$650/moWegovy Tablets$149/mo
- Savings cardContrave—Wegovy Tablets—
- Medicare BridgeContraveTier 3Wegovy Tablets$50/mo ✓
- A1c reductionContrave—Wegovy Tablets—
- FDA approvedContrave2014-09Wegovy Tablets2025-12
Pick Contrave if…
Pick Wegovy Tablets if…
- You're on Medicare and want the $50/mo Bridge price
- Cash pay matters more than peak weight loss ($149/mo cheaper)
- You want the higher peak efficacy (15% vs 9%)
Not sure which fits?
The 30-second matcher on the homepage scores every 2026 GLP-1 against your goals + preferences and recommends the best fit.